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HERDIN Record #: NCR-SLMCCM-18101018083833 Submitted: 10 October 2018 Modified: 19 October 2018

A PILOT STUDY ON SINGLE NUCLEOTIDE POLYMORPHISMS OF CATHECHOL- METHYLTRANSFERASE (VALI58MET) AND CYP2D6*10 (PRO34SER) AND OPIOID USE AMONG CANCER PAIN PATIENTS.

Francis O. Javier,
Antonio B. Yap,
Merlina L. Cabrera,
Lyde A. Magpantay,
Cynthia A. Mapua,
Maria Luisa  G. Daroy,
Michael  O. Baclig

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A hospital-based  cross-sectional  study was conducted to e  aluate  the association between catechol-0-methyltransferase COMT)  and CYP2D6*  I 0 single  nucleotide  polymorphisms (SNPs)  and opioid consumption  among cancer pain patients. COMT  and  CYP2D6*   10 genotyping     was  performed    by polymerase      chain   reaction-restriction        fragment    length polymorphism     (PCR-RFLP).    In  this   study,   there  was  no association   noted  between  COMT  genotype  and dosage  of morphine.  The odds of moderate to high morphine use among patients   with    Val/Val   genotype   were   I. 78  times    higher compared  to those  with Val/Met  genotype.   For CYP206*  10


S   Ps,  there was no association  noted when  various   doses of tramadol     were  compared   against   the  three   CYP206*   10 genotypes      (Homozygous    CIC;     Heterozygous    CIT   and Homozygous  TIT).      In  conclusion,  there  was no association een  in  both  the  pain candidate   genes,  COMT (Vall  58Met) and CYP2D6* l 0 (Pro34Ser) and opioid use among cancer pain patients.


 


Key  words.   COMT;  CYP206*  l O;    Cancer  Pain;   SNPs; Opioids


 


 


 

Publication Type
Journal
Publication Sub Type
Journal Article, Original
Title
St. Luke's Healthcare Journal
Frequency
Semi-Annual
Publication Date
July-December 2016
Volume
11
Issue
2
Page(s)
55-62
LocationLocation CodeAvailable FormatAvailability
St. Luke Abstract Print Format
1. Mercadante S,, , Fulfaro F., . "World Health Organization guidelines for cancer pain: A reappraisal." Ann Oncol 16(4): 32-5, 2005