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HERDIN Record #: PCHRD02221109020890 Submitted: 22 February 2011 Modified: 03 November 2017

Risk factors associated with malignant endometrial lesions in postmenopausal women presenting with abnormal uterine bleeding: A retrospective review.

Irene L. Uy,
Ma.Asuncion Fernandez,
Brenda Bernadette P. Bautista-Zamora

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OBJECTIVES: To identify clinical, sonographic and hysteroscopic characteristics associated with malignant endometrial lesions.


METHODS: This is a retrospective descriptive study that included all menopausal women presenting with vaginal bleeding in a tertiary care hospital from January 2007 to June 2010. Clinical, sonographic and hysteroscopic findings were evaluated as predictor variables for development of endometrial adenocarcinoma.


RESULTS: Thirteen out of the 215 patients had endometrioid adenocarcinoma, in women presenting with postmenopausal bleeding, with a prevalence rate of 6%. A trend towards harm is seen among the following factors: age of > 60 years (OR 1.19; 95% CI, 0.29-4.46), menarche < 12 years (OR 1.07; 95% CI, 0.22-4.66), endometrial stripe >/- 10mm (OR 2.02; 95% CI, 0.58-7.09), lesion of diameter < 1cm (OR 1.57; 95% CI, 0.45-5.74), presence of cystic space (OR 4.28; 95% CI, 1.00-17.36), and soft consistency (OR 1.94; 95% CI, 0.47-9.21).


CONCLUSION: Increasing age, early onset of menarche, endometrial thickness of >/- 10mm, hysteroscopic characteristics (lesion diameter of less than 1 em, presence of cystic space and soft consistency) increases the probability of carcinoma.

Publication Type
Journal
Publication Sub Type
Journal Article, Original
Title
Philippine Journal of Reproductive Endocrinology and Infertility
Frequency
Annual
Publication Date
January-December 2010
Volume
7
Page(s)
1-6
LocationLocation CodeAvailable FormatAvailability
Philippine Council for Health Research and Development Library Box No. 2 Fulltext Print Format (Request Document)
Philippine Council for Health Research and Development Library Box No. 2 Fulltext pdf (Request Document)
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