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HERDIN Record #: PCHRD071008020742 Submitted: 08 July 2008 Modified: 08 July 2008

Lung function tests of toluene abusers among urban street children ages 7-18 years old.

Nerissa A. De Leon,
Milagros S. Bautista,
Fatima Pogoy,
Teresita S. De Guia

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BackgroundÃÆ'Æ'Æ’ÃÆ'†â€™ÃÆ'Æ'â€Ã...¡ÃÆ'‚¢ÃÆ'Æ'Æ’ÃÆ'¢â‚¬Ã...¡ÃÆ'Æ'¢ÃÆ'¢â‚¬Ã...¡ÃÆ'‚¬ÃÆ'Æ'Æ’ÃÆ'¢â‚¬Ã...¡ÃÆ'Æ'¢ÃÆ'¢â€Ã...¡Ã‚¬ÃÆ'‚ Toluene, an industrial solvent found in adhesive compound, is the most commonly abused inhalant among street children in Metro Manila. 1 his study aims to determine some of the physiologic effects of toluene inhalation on the respiratory function of the study population.

Methods and Results General health status was assessed by history, physical examination and a questionnaire with emphasis on the respiratory symptoms. Thirty one (31) street children, 26 (83.8 percent) males, 5 (16.1 percent) females, with a mean age of 14 +/- 2.23 years were included in the study. The mean duration of drug use is 2.6 +/- 2.5 years at a frequency of 23 +/- 20 hours per week. The most common respiratory symptoms in this series included dyspnea (38.71 percent), cough (35.48 percent), rhinorrhea (29.03 percent) and choking (12.9 percent). Results of the spirometric studies showed restrictive pattern (FVC < 80 percent predicted) in 13(41.9 percent) subjects positive for toluene in the blood. Of the 13 subjects, 5 (39 percent) had mild restrictive, 6 (46 percent) moderately restrictive and 2(15 percent) with moderately severe restrictive ventilatory pattern. FEV1 values were all normal (mean FEV, 89 +/- 14.90). There was a statistically significant correlation between the duration / frequency of inhalant abuse with toluene levels in the blood (p=0.04) and urine (p value=0.006).

Conclusion ÃÆ'Æ'Æ’ÃÆ'†â€™ÃÆ'Æ'â€Ã...¡ÃÆ'‚¢ÃÆ'Æ'Æ’ÃÆ'¢â‚¬Ã...¡ÃÆ'Æ'¢ÃÆ'¢â‚¬Ã...¡ÃÆ'‚¬ÃÆ'Æ'Æ’ÃÆ'¢â‚¬Ã...¡ÃÆ'Æ'¢ÃÆ'¢â€Ã...¡Ã‚¬ÃÆ'‚ This study, therefore demonstrates the effects of chronic toluene abuse on the pulmonary function of children. (Author)

Publication Type
Journal
Publication Sub Type
Announcements
Title
Philippine Heart Center Journal
Frequency
Quarterly
Publication Date
April-June 2006
Volume
12
Issue
2
Page(s)
26-30

Objectives

General objective: To determine the effects of inhaling toluene on the pulmonary function among urban street children 7-18 years of age.

Specific objectives:
1. To describe the demographic profile and symptomatology of toluene users in children 7-18 years of age.
2. To determine the relationship of pulmonary function studies with the duration of toluene use.
3. To determine the relationship of pulmonary function with the levels of toluene in the blood and urine.

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Philippine Council for Health Research and Development Library Abstract Print Format (Request Document)