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HERDIN Record #: PCHRD020808010222 Submitted: 08 February 2008 Modified: 08 September 2012

Comparison of three protocols for Controlled Ovarian Hyperstimulation (COH) for clomiphene citrate poor responders.

Maria Lourdes Zosas-Cabling,
Ma. Concepcion Ilao-Oreta

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Objective:
To compare the efficacy of Letrozole and Gonadotropin, given alone or in combination, in controlled ovarian hyperstimulation in Clomiphene citrate poor responders.

Study Design:
Prospective, non-randomized observational study on Clomiphene citrate poor responders at the St. Luke's Medical Center setting from January to July 2006.

Results:
Letrozole and gonadotropins, whether given alone or in combination, have similar clinical outcomes in terms of endometrial thickness during ovulation and the number of dominant follicles developed. The use of gonadotropins results in 100% ovulation rate, similar to results when Letrozole is used as an adjunct. Letrozole significantly reduces the dose of gonadotropin required to develop a mature follicle.

Conclusion:
Since the use of Letrozole and gonadotropins for ovarian hyperstimulation had similar results, Letrozole has the advantage of reduced cost and greater patient acceptance. It may be used alone or in conjunction with gonadotropins for poor responders to Clomiphene citrate.

Publication Type
Journal
Publication Sub Type
Journal Article, Original
Title
Philippine Journal of Reproductive Endocrinology and Infertility
Frequency
Semi-Annual
Publication Date
January-June 2007
Volume
4
Issue
1
Page(s)
7-12

Objectives

To compare the efficacy of Letrozole and Gonadotropin, given alone or in combination, in controlled ovarian hyperstimulation in Clomiphene citrate poor responders.

LocationLocation CodeAvailable FormatAvailability
Philippine Council for Health Research and Development Library Box No. 2 Fulltext Print Format (Request Document)
Philippine Council for Health Research and Development Library Box No. 2 Fulltext pdf (Request Document)
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2. AL Fosan, H , Al-Khaduri, M , Tan, SL , Tulandi, T . "A randomized trial of Letrozle versus Clomiphene citrate in women undergoing superovulation" Fertil Steril 82, 1561-1563, 2004. Retrieved from: http://www.ncbi.nlm.nih.gov/pubmed/15589860
3. Mitwally, M , Casper, R . "Aromatase inhibition reduces the dose of gonadotropin required for controlled ovarian hyperstimulation" J Soc Gynecol Invest 11, 406-415, 2004. Retrieved from: http://www.ncbi.nlm.nih.gov/pubmed/15350255